Wang Wen-Liang, Liu Pei-Pei, Zhang Ya-Peng, Li Jing, Tao Hong-Wen, Gu Qian-Qun, Zhu Wei-Ming
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Arch Pharm Res. 2009 Sep;32(9):1211-4. doi: 10.1007/s12272-009-1904-8. Epub 2009 Sep 26.
A new hopane type pentacyclic triterpenoid, 2-hydroxydiplopterol (1) has been isolated from the metabolites produced by the halotolerant fungal strain Aspergillus variecolor B-17. The structure of 1 was determined by spectroscopic methods and single crystal X-Ray diffraction analysis. 2-Hydroxydiplopterol (1) exhibited cytotoxicity against K562 cells with an IC50 value of 22 microM.
一种新的藿烷型五环三萜化合物，2-羟基双翅醇（1）已从耐盐真菌杂色曲霉B-17产生的代谢产物中分离出来。化合物1的结构通过光谱方法和单晶X射线衍射分析确定。2-羟基双翅醇（1）对K562细胞表现出细胞毒性，IC50值为22微摩尔。
