Department of General Surgery, Ankara Training and Research Hospital, Ankara 06340, Turkey.
Surg Today. 2009;39(10):876-83. doi: 10.1007/s00595-009-3972-2. Epub 2009 Sep 27.
To determine the effect of octreotide, octreotide with zinc, levamisole, and misoprostol on the bacterial translocation that develops in rats with acute pancreatitis (AP).
A total of 36 rats were divided into six groups, each consisting of six rats. Only laparotomy was performed on the first group. Acute pancreatitis was performed on the second group. Octreotide was given to the third, fourth, fifth, and sixth groups. Octreotide, octreotide with zinc, levamisole, and misoprostol were given to groups III, IV, V, VI, respectively. Rats were euthanized 48 h after the occurrence of AP. Blood and mesenteric lymph node samples were collected for polymerase chain reaction (PCR). Pancreatic tissue and terminal ileum were obtained for histopathological examinations.
The severity of pancreatitis and mucosal damage of the terminal ileum was higher in group II than groups I, III, IV, V, and VI, histopathologically (P < 0.05). There wasn't a significant difference with respect to OA with Zn or L or M and OA group (P > 0.05). A significant difference was found in PCR positivity in blood and mesenteric lymph node between groups I and II (P < 0.05).
In AP, administering octreotide alone significantly prevented the bacterial translocation by preventing mucosal damage. The zinc, levamisole, or misoprostol with octreotide did not influence the results.
确定奥曲肽、奥曲肽锌、左旋咪唑和米索前列醇对急性胰腺炎（AP）大鼠发生细菌易位的影响。
36 只大鼠分为 6 组，每组 6 只。第一组仅行剖腹术。第二组行急性胰腺炎手术。第三、四、五、六组给予奥曲肽。第三、四、五、六组分别给予奥曲肽、奥曲肽锌、左旋咪唑和米索前列醇。AP 发生后 48 小时处死大鼠。采集血和肠系膜淋巴结标本进行聚合酶链反应（PCR）。取胰腺组织和末端回肠进行组织病理学检查。
组织病理学检查显示，与第一、三、四、五、六组相比，第二组大鼠的胰腺炎严重程度和末端回肠黏膜损伤更高（P < 0.05）。奥曲肽锌或 L 或 M 与奥曲肽组相比，差异无统计学意义（P > 0.05）。第一组和第二组之间血液和肠系膜淋巴结 PCR 阳性率存在显著差异（P < 0.05）。
在 AP 中，单独给予奥曲肽可通过防止黏膜损伤来显著预防细菌易位。奥曲肽与锌、左旋咪唑或米索前列醇联合使用并不影响结果。
