Ohno T, Park P, Oguro K, Takeda H, Omata M, Takayama H, Fujinuma A, Abe M
Ultrastruct Pathol. 1986;10(4):321-30. doi: 10.3109/01913128609064196.
A lesion in the left humeral head of a 15-year-old Japanese boy was light-microscopically diagnosed as clear cell chondrosarcoma. Fresh tissues from the lesion were studied ultrastructurally. In most tumor cells, that is, clear cells, paucity of organelles, sparse free ribosomes, and low protein content in cytosol were most striking. Tumor cells had many microvilli characteristic of cartilage cells. Among scanty organelles, vesicles or cisternae of dilated rough endoplasmic reticulum were rather conspicuous, and well-developed Golgi complexes were sparse. Intercellular matrix was scanty. These results suggest that intercellular matrix substance may be synthesized substantially by rough endoplasmic reticulum, whereas the synthesized substance perhaps cannot be transported smoothly into extracellular spaces because of scanty well-developed Golgi complexes.
一名15岁日本男孩左肱骨头的病变经光学显微镜诊断为透明细胞软骨肉瘤。对该病变的新鲜组织进行了超微结构研究。在大多数肿瘤细胞，即透明细胞中，细胞器稀少、游离核糖体稀疏以及胞质溶胶中蛋白质含量低最为显著。肿瘤细胞有许多软骨细胞特有的微绒毛。在稀少的细胞器中，扩张的粗面内质网的囊泡或潴泡相当明显，发育良好的高尔基体复合体稀少。细胞间基质稀少。这些结果表明，细胞间基质物质可能主要由粗面内质网合成，而由于发育良好的高尔基体复合体稀少，合成的物质可能无法顺利运输到细胞外空间。
