Le Charpentier Y, Forest M, Postel M, Tomeno B, Abelanet R
Cancer. 1979 Aug;44(2):622-9. doi: 10.1002/1097-0142(197908)44:2<622::aid-cncr2820440232>3.0.co;2-e.
Five cases of clear-cell variant of chondrosarcoma (Unni et al.) are reported. The tumors occurred in the epiphyseal region of long bones; three in the femoral head. Roentgenographically, the lesion was usually a well-defined and benign appearing one, either purely lytic (3 cases) or with central radiodensity (2 cases). Histologically, all five cases had areas of conventional chondrosarcoma; however, the greater portion of the tumor was made up of sheets of clear-cells intermixed with nonneoplastic bone trabeculae but devoid of chondroid matrix. Electron microscopic studies showed that these clear-cells possess cytoplasmic microvilli, abundant glycogen particles and prominent golgi complexes, like normal or tumorous chondroid cells usually have. In our experience, the best treatment seemed to be en bloc resection with joint replacement; indeed, despite the fact that they are true chondrosarcomas, these tumors usually have a very slow rate of growth.
本文报告了5例软骨肉瘤透明细胞变异型（Unni等人）。肿瘤发生在长骨的骨骺区域；3例位于股骨头。X线表现上，病变通常边界清晰，呈良性表现，要么为单纯溶骨性（3例），要么中央有放射密度影（2例）。组织学上，所有5例均有传统型软骨肉瘤区域；然而，肿瘤的大部分由成片的透明细胞组成，这些透明细胞与非肿瘤性骨小梁混合，但无软骨样基质。电子显微镜研究表明，这些透明细胞具有细胞质微绒毛、丰富的糖原颗粒和明显的高尔基体，这与正常或肿瘤性软骨样细胞通常具有的特征相似。根据我们的经验，最佳治疗方法似乎是整块切除并进行关节置换；实际上，尽管这些肿瘤是真正的软骨肉瘤，但它们的生长速度通常非常缓慢。
