Iwasawa Atsuo, Niwano Yoshimi, Mokudai Takayuki, Kohno Masahiro
Tissue Culture Laboratory, Showa University Fujigaoka Hospital, 1-30, Fujigaoka, Aoba-ku, Yokohama, Kanagawa 227-8501, Japan.
Biocontrol Sci. 2009 Sep;14(3):107-11. doi: 10.4265/bio.14.107.
Proanthocyanidin, which consists of (+) catechin, (-) epicatechin and their gallates (15%), (-) epicatechin gallate-dimers, -trimers, and -tetramers (80%), and (-) epicatechin gallate-pentamers, -hexamers, and -heptamers (5%), was evaluated for its antiviral activity against feline calicivirus F9 strain (FCV/F9), which is thought to be a surrogate for noroviruses, and coxsackievirus A7 strain (Cox.A7), which was selected as a representative enteric virus. To achieve a viral inactivation rate of 99% or greater after contact for 10 sec., at least 1 mg/ml and 10 mg/ml of proanthocyanidin were required against FCV/F9 and Cox.A7, respectively. Although the antiviral mechanism of proanthocyanidin is not clear at present, proanthocyanidin may be an effective disinfectant against enteroviruses such as noroviruses.
原花青素由（+）儿茶素、（-）表儿茶素及其没食子酸盐（15%）、（-）表儿茶素没食子酸酯二聚体、三聚体和四聚体（80%）以及（-）表儿茶素没食子酸酯五聚体、六聚体和七聚体（5%）组成，对猫杯状病毒F9株（FCV/F9，被认为是诺如病毒的替代物）和柯萨奇病毒A7株（Cox.A7，被选为代表性肠道病毒）的抗病毒活性进行了评估。为了在接触10秒后达到99%或更高的病毒灭活率，针对FCV/F9和Cox.A7分别至少需要1毫克/毫升和10毫克/毫升的原花青素。尽管原花青素的抗病毒机制目前尚不清楚，但原花青素可能是一种针对诺如病毒等肠道病毒的有效消毒剂。
