Ubbink Dirk Th, Vermeulen Hester, Lubbers Maarten J, Voss Andreas
Academisch Medisch Centrum/Universiteit van Amsterdam, Afd. Kwaliteit en Procesinnovatie, Amsterdam, The Netherlands.
Ned Tijdschr Geneeskd. 2009;153:B328.
Antiseptics are commonly applied to prevent or treat wound infections. Many common opinions about antiseptics appear not to be supported by convincing evidence. The aim of this review is to compare such traditional beliefs with currently available evidence. While antiseptics obviously reduce the number of pathogens, their value as a supplement to or as replacement of wound cleansing remains unclear.Some antiseptics encourage wound healing, others may even delay it. Many of the adverse effects ascribed to antiseptics are not supported by evidence; nevertheless this has resulted in a reduction of their use.If used as part of a multifaceted approach to wound care, antiseptics are to be preferred over locally applied antibiotics as they are safer, have a broader spectrum of activity (particularly against antibiotic-resistant bacteria), and rarely lead to resistance.
防腐剂通常用于预防或治疗伤口感染。许多关于防腐剂的普遍观点似乎并没有令人信服的证据支持。本综述的目的是将这些传统观念与现有证据进行比较。虽然防腐剂显然能减少病原体数量，但其作为伤口清洁补充剂或替代品的价值仍不明确。一些防腐剂促进伤口愈合，另一些甚至可能延迟愈合。许多归因于防腐剂的不良反应并无证据支持；然而，这导致了其使用的减少。如果作为伤口护理多方面方法的一部分使用，防腐剂比局部应用抗生素更可取，因为它们更安全，具有更广泛的活性谱（特别是针对耐抗生素细菌），并且很少导致耐药性。
