Jones G M
Philos Trans R Soc Lond B Biol Sci. 1977 Apr 26;278(961):319-34. doi: 10.1098/rstb.1977.0045.
Human subjects with maintained reversal of their horizontal field of vision exhibit very substantial adaptive changes in their 'horizontal' vestibulo-ocular reflex (v.o.r.). Short durations (8 min) of vision reversal during natural head movement led to 20% v.o.r. attenuation while long periods (4 weeks) eventually led to approximate reversal of the reflex. The reversed condition is approached by a complex, but highly systematic, series of changes in gain and phase of the reflex response relative to normal. Recovery after return to normal vision exhibits a similar duration, but different pattern, to that of the original adaptation. A chronic cat preparation with long-term optical reversal of vision has now been developed and shows similar adaptive and recovery changes at low test stimulus amplitudes, but different patterns of adaptive response at high amplitudes. An adaptive neural model employing known vestibulo-ocular pathways is proposed to account for these experimentally observed plastic changes. The model is used to predict the adapted response to patterns of stimulation extending beyond the range of experimental investigation.
水平视野维持反转的人类受试者在其“水平”前庭眼反射（VOR）中表现出非常显著的适应性变化。在自然头部运动期间，短时间（8分钟）的视觉反转会导致VOR衰减20%，而长时间（4周）最终会导致反射近似反转。相对于正常情况，反射反应的增益和相位会发生一系列复杂但高度系统的变化，从而接近反转状态。恢复到正常视觉后的恢复过程与原始适应过程具有相似的持续时间，但模式不同。现已开发出一种长期视觉光学反转的慢性猫制备方法，在低测试刺激幅度下显示出相似的适应性和恢复变化，但在高幅度下具有不同的适应性反应模式。提出了一种采用已知前庭眼通路的适应性神经模型来解释这些实验观察到的可塑性变化。该模型用于预测对超出实验研究范围的刺激模式的适应反应。
