KIT (Royal Tropical Institute) Biomedical Research, Meibergdreef 39, 1105 AZ Amsterdam, The Netherlands.
Vaccine. 2009 Nov 23;27(50):7125-8. doi: 10.1016/j.vaccine.2009.09.054. Epub 2009 Sep 26.
BCG vaccination and rifampicin chemoprophylaxis are both strategies for leprosy prevention. While the combined effect is unknown, the combination may give the desired push to halt leprosy transmission. Secondary analysis was done on results from a single centre, double blind, cluster randomized, and placebo-controlled trial. Individually, BCG (given at infancy) and rifampicin showed to protect against leprosy (57% [95% CI: 24-75%] and 58% [95% CI: 30-74%], respectively). The combined strategies showed a protective effect of 80% (95% CI: 50-92%). This is the first time that the additive effect of BCG and rifampicin are shown; the combined strategies can possibly lower leprosy incidence.
BCG 疫苗接种和利福平化学预防都是预防麻风病的策略。虽然联合效果尚不清楚，但这种组合可能会对阻止麻风病传播起到预期的推动作用。这是对一项单中心、双盲、整群随机、安慰剂对照试验结果的二次分析。单独使用 BCG（在婴儿期接种）和利福平都显示出对麻风病的保护作用（分别为 57%[95%CI：24-75%]和 58%[95%CI：30-74%]）。联合策略显示出 80%的保护作用（95%CI：50-92%）。这是首次显示 BCG 和利福平的累加效应；联合策略可能会降低麻风病的发病率。
