Cuturic Miroslav, Abramson Ruth K, Vallini Daniel, Frank Elaine M, Shamsnia Morteza
Department of Neuropsychiatry, University of South Carolina School of Medicine, Columbia, SC 29203, USA.
Behav Sleep Med. 2009;7(4):245-54. doi: 10.1080/15402000903190215.
Polysomnographic sleep patterns in Huntington's disease (HD) have been studied sporadically in small groups of patients, providing variable results. In this study, by comparing the polysomnographic sleep patterns of HD patients and their unaffected relatives, identifying sleep traits more specifically related to the HD gene was attempted. The results corroborated previously reported findings of prolonged sleep latency and the virtual absence of nocturnal respiratory disturbances in early HD. Sleep latency in the HD patients positively correlated with the results of a screening test for frontal lobe dysfunction. Larger, more standardized studies will be needed to correlate genetic markers and sleep patterns in HD.
亨廷顿舞蹈症（HD）患者的多导睡眠图睡眠模式已在小部分患者群体中进行了零星研究，结果不一。在本研究中，通过比较HD患者及其未患病亲属的多导睡眠图睡眠模式，试图更具体地确定与HD基因相关的睡眠特征。结果证实了先前报道的早期HD患者睡眠潜伏期延长以及夜间几乎不存在呼吸障碍的发现。HD患者的睡眠潜伏期与额叶功能障碍筛查测试结果呈正相关。需要进行更大规模、更标准化的研究，以关联HD中的基因标记和睡眠模式。
