Fisch P, Malkovsky M, Kovats S, Sturm E, Braakman E, Klein B S, Voss S D, Morrissey L W, DeMars R, Welch W J
Department of Human Oncology, University of Wisconsin, Madison 53792.
Science. 1990 Nov 30;250(4985):1269-73. doi: 10.1126/science.1978758.
All human gamma delta T cells coexpressing the products of the variable (V) region T cell receptor (TCR) gene segments V gamma 9 and V delta 2 recognize antigens from mycobacterial extracts and Daudi cells. Exogenous and endogenous ligands on the cell surface, homologous to the groEL heat shock family, induced reactivities that resembled superantigen responses in this major subset of human peripheral blood gamma delta T cells. Stimulation of human V gamma 9/V delta 2 T cells is not restricted by human leukocyte antigens (HLA), including nonpolymorphic beta 2-microglobulin (beta 2M)-associated class Ib molecules. These data may be important for understanding the role of gamma delta T cells in autoimmunity and in responses to microorganisms and tumors.
所有共表达可变（V）区T细胞受体（TCR）基因片段Vγ9和Vδ2产物的人类γδT细胞，都能识别来自分枝杆菌提取物和Daudi细胞的抗原。细胞表面与groEL热休克家族同源的外源性和内源性配体，在人类外周血γδT细胞的这一主要亚群中诱导出类似于超抗原反应的反应性。人类Vγ9/Vδ2 T细胞的刺激不受人类白细胞抗原（HLA）的限制，包括与非多态性β2-微球蛋白（β2M）相关的Ib类分子。这些数据对于理解γδT细胞在自身免疫以及对微生物和肿瘤的反应中的作用可能很重要。
