Hussain Syed Ahmer, Haider Shaheen Kamran, Ullah Muhammad Saad, Furqan Aamir
Ophthalmology, District Headquarter Teaching Hospital, Dera Ghazi Khan, PAK.
Anesthesiology, Chaudhry Pervaiz Elahi Institute of Cardiology, Multan, PAK.
Cureus. 2020 Jan 1;12(1):e6535. doi: 10.7759/cureus.6535.
Study objective The objective of this study was to compare pterygium excision with amniotic membrane graft and that with stem cell graft in terms of pterygium recurrence, using a quasi-experimental study design. This study was conducted at the department of ophthalmology at Nishtar Hospital, Multan, Pakistan from January to September 2019. Methodology and results A total of 214 patients who presented to the outpatient section at the department of ophthalmology were included in this study. A lottery method was used to divide the patients into two equal groups: A and B. Patients in group A underwent pterygium excision with amniotic membrane graft, and patients in group B underwent pterygium excision with stem cell grafts. Follow-ups were planned for the third day, the second week, the first month, the third month, and the sixth month postoperatively. Frequency and percentage were calculated for qualitative variables and for quantitative data. Mean and standard deviation were calculated, and a p-value of <0.05 was considered significant. Postoperative complications (i.e., graft edema, hemorrhage, and recurrence) in group A were observed as n = 0 (0%), n = 11 (10.3%), and n = 15 (14%), respectively. Postoperative complications (i.e., graft edema, hemorrhage, and recurrence) in group B were observed as 15%, 3.7%, and 12.1%, respectively. Statistically, the difference for graft edema was significant (p = 0.000). Conclusion Stem cell grafting after pterygium excision was not associated with any major complications postoperatively. Stem cell grafting is better in terms of cosmetic appearance and has less recurrence rate as compared to amniotic membrane transplantation.
研究目的 本研究的目的是采用准实验研究设计，比较翼状胬肉切除联合羊膜移植术与翼状胬肉切除联合干细胞移植术在翼状胬肉复发方面的效果。本研究于2019年1月至9月在巴基斯坦木尔坦尼什塔尔医院眼科进行。方法与结果 本研究共纳入214例到眼科门诊就诊的患者。采用抽签法将患者分为两组，A组和B组，每组人数相等。A组患者接受翼状胬肉切除联合羊膜移植术，B组患者接受翼状胬肉切除联合干细胞移植术。计划在术后第三天、第二周、第一个月、第三个月和第六个月进行随访。对定性变量和定量数据计算频率和百分比。计算均值和标准差，p值<0.05被认为具有统计学意义。A组术后并发症（即移植片水肿、出血和复发）分别观察到n = 0（0%）、n = 11（10.3%）和n = 15（14%）。B组术后并发症（即移植片水肿、出血和复发）分别观察到15%、3.7%和12.1%。在统计学上，移植片水肿的差异具有显著性（p = 0.000）。结论 翼状胬肉切除术后干细胞移植术后未出现任何重大并发症。与羊膜移植相比，干细胞移植在外观方面更好，复发率更低。
