Pariente J A, Madrid J A, Salido G M
Department of Physiology, Faculty of Veterinary Science, University of Extremadura, Caceres, Spain.
Exp Physiol. 1990 Sep;75(5):657-67. doi: 10.1113/expphysiol.1990.sp003444.
An investigation was made of the effects of H1 and H2 receptor agonists and antagonists on rabbit pancreatic exocrine secretion stimulated by secretin and cholecystokinin (CCK). The H1 agonist 2-thiazolylethylamine elicited dose-dependent increases in the rate of secretion. Increases in pancreatic juice flow and enzyme output were also noted after H2 antagonist cimetidine. In contrast, the H1 antagonist chlorpheniramine and H2 agonist dimaprit caused reductions in flow and enzyme output. The results suggest that H1 receptors have stimulative effects and H2 receptors have inhibitory effects on exocrine rabbit pancreas.
研究了H1和H2受体激动剂及拮抗剂对由促胰液素和胆囊收缩素（CCK）刺激的兔胰腺外分泌的影响。H1激动剂2-噻唑基乙胺引起分泌速率呈剂量依赖性增加。H2拮抗剂西咪替丁后也观察到胰液流量和酶输出增加。相反，H1拮抗剂氯苯那敏和H2激动剂二甲双胍导致流量和酶输出减少。结果表明，H1受体对兔胰腺外分泌有刺激作用，H2受体有抑制作用。
