Alcón S, Pozo M J, Salido G M, Pariente J A
Department of Physiology, Faculty of Veterinary Science, University of Extremadura, Cáceres, Spain.
Inflamm Res. 1995 May;44(5):207-11. doi: 10.1007/BF01782260.
The effects of histamine upon secretin- or cholecystokinin (CCK)-evoked exocrine pancreatic secretion were investigated in the anaesthetised guinea pig. Histamine (0.1 mumol/kg/min) induced a slight increase in pancreatic juice flow and total protein release compared to saline controls. Secretin (0.5 pmol/kg/min) and CCK-8 (0.75 pmol/kg/min) evoked marked time course increases in both the rate of pancreatic juice flow and total protein output in the anaesthetised guinea pig. Administration of either secretin or CCK-8 simultaneously with histamine elevated the exocrine pancreatic secretion compared to the smaller response obtained when administered separately. These results indicate that histamine may play an important physiological role in modulating the hormonal control of exocrine guinea pig pancreas.
在麻醉的豚鼠中研究了组胺对促胰液素或胆囊收缩素（CCK）诱发的胰腺外分泌的影响。与生理盐水对照组相比，组胺（0.1μmol/kg/分钟）使胰液分泌量和总蛋白释放量略有增加。促胰液素（0.5pmol/kg/分钟）和CCK-8（0.75pmol/kg/分钟）在麻醉的豚鼠中引起胰液分泌速率和总蛋白输出量随时间显著增加。与单独给药时获得的较小反应相比，促胰液素或CCK-8与组胺同时给药可提高胰腺外分泌。这些结果表明，组胺可能在调节豚鼠胰腺外分泌的激素控制中发挥重要的生理作用。
