Fructose takes a toll.
作者信息
Vos Miriam B, McClain Craig J
出版信息
Hepatology. 2009 Oct;50(4):1004-6. doi: 10.1002/hep.23212.
Abstract
摘要
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Fructose takes a toll.果糖有害。
Hepatology. 2009 Oct;50(4):1004-6. doi: 10.1002/hep.23212.
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Toll-like receptor 4 status influences hepatic metabolism, although its interaction with a high-fructose, energy, and prebiotic diet remains uncertain.Toll样受体4的状态会影响肝脏代谢，尽管其与高果糖、高热量及益生元饮食之间的相互作用仍不明确。
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本文引用的文献
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Fructose and oxidized low-density lipoprotein in pediatric nonalcoholic fatty liver disease: a pilot study.儿童非酒精性脂肪性肝病中的果糖与氧化型低密度脂蛋白：一项初步研究。
Arch Pediatr Adolesc Med. 2009 Jul;163(7):674-5. doi: 10.1001/archpediatrics.2009.93.
2
The role of the gut microbiota in energy metabolism and metabolic disease.肠道微生物群在能量代谢和代谢性疾病中的作用。
Curr Pharm Des. 2009;15(13):1546-58. doi: 10.2174/138161209788168164.
3
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.摄入果糖甜味而非葡萄糖甜味的饮料会增加超重/肥胖人群的内脏脂肪和血脂，并降低胰岛素敏感性。
J Clin Invest. 2009 May;119(5):1322-34. doi: 10.1172/JCI37385. Epub 2009 Apr 20.
4
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity.饱和脂肪酸主要通过激活下丘脑的TLR4信号传导产生炎症反应：对肥胖发病机制的影响。
J Neurosci. 2009 Jan 14;29(2):359-70. doi: 10.1523/JNEUROSCI.2760-08.2009.
5
Bacterial endotoxin stimulates adipose lipolysis via toll-like receptor 4 and extracellular signal-regulated kinase pathway.细菌内毒素通过Toll样受体4和细胞外信号调节激酶途径刺激脂肪组织脂解。
J Biol Chem. 2009 Feb 27;284(9):5915-26. doi: 10.1074/jbc.M807852200. Epub 2009 Jan 3.
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Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study.益生菌可恢复肠道菌群并改善人类酒精性肝损伤中的肝酶：一项初步研究。
Alcohol. 2008 Dec;42(8):675-82. doi: 10.1016/j.alcohol.2008.08.006.
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Chylomicrons promote intestinal absorption of lipopolysaccharides.乳糜微粒促进脂多糖的肠道吸收。
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Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey.美国儿童和成人膳食果糖摄入量：第三次全国健康和营养检查调查
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TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol.TRIF和IRF-3与TNF启动子的结合导致慢性乙醇诱导的巨噬细胞TNF失调和脂肪变性。
J Immunol. 2008 Sep 1;181(5):3049-56. doi: 10.4049/jimmunol.181.5.3049.
10
Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake.人类非酒精性脂肪性肝病与血浆内毒素及纤溶酶原激活物抑制剂1浓度升高以及果糖摄入有关。
J Nutr. 2008 Aug;138(8):1452-5. doi: 10.1093/jn/138.8.1452.
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