Mireku Nana, Wang Yun, Ager Joel, Reddy Raju C, Baptist Alan P
Division of Allergy and Immunology; Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan, USA.
Ann Allergy Asthma Immunol. 2009 Sep;103(3):220-4. doi: 10.1016/S1081-1206(10)60185-8.
Pediatric asthma exacerbations may correlate with changes in weather, yet this relationship is not well defined.
To determine the effects of fluctuations in climatic factors (temperature, humidity, and barometric pressure) on pediatric asthma exacerbations.
A retrospective study was performed at 1 large urban hospital during a 2-year period (January 1, 2004, to December 31, 2005). Children presenting to the emergency department (ED) for an asthma exacerbation were included. Data on climactic factors, pollutants, and aeroallergens were collected daily. The relationship of daily (intraday) or between-day (interday) changes in climactic factors and asthma ED visits was evaluated using time series analysis, controlling for seasonality, air pollution, and aeroallergen exposure. The effects of climactic factors were evaluated on the day of admission (T=0) and up to 5 days before admission (T-5 through T-1).
There were 25,401 asthma ED visits. A 10% intraday increase in humidity on day T-1 or day T-2 was associated with approximately 1 additional ED visit for asthma (P < .001 and P = .01, respectively). Interday changes in humidity from day T - 3 to T-2 were also associated with more ED visits (P < .001). Interday changes in temperature from T-1 to T = 0 increased ED visits, with a 10 degrees F increase being associated with 1.8 additional visits (P = .006). No association was found with changes in barometric pressure.
Fluctuations in humidity and temperature, but not barometric pressure, appear to influence ED visits for pediatric asthma. The additional ED visits occur 1 to 2 days after the fluctuation.
儿童哮喘急性发作可能与天气变化有关，但这种关系尚未明确界定。
确定气候因素（温度、湿度和气压）波动对儿童哮喘急性发作的影响。
在一家大型城市医院进行了一项为期2年（2004年1月1日至2005年12月31日）的回顾性研究。纳入因哮喘急性发作到急诊科就诊的儿童。每天收集气候因素、污染物和空气过敏原的数据。使用时间序列分析评估气候因素的每日（日内）或日间（日间）变化与哮喘急诊就诊之间的关系，同时控制季节性、空气污染和空气过敏原暴露。在入院当天（T=0）以及入院前5天（T-5至T-1）评估气候因素的影响。
共有25401次哮喘急诊就诊。在T-1天或T-2天湿度日内增加10%与哮喘急诊就诊次数增加约1次相关（分别为P <.001和P =.01）。从T - 3天到T-2天湿度的日间变化也与更多的急诊就诊相关（P <.001）。从T-1天到T = 0天温度的日间变化增加了急诊就诊次数，温度升高10华氏度与增加1.8次就诊相关（P =.006）。未发现与气压变化有关联。
湿度和温度的波动，而非气压，似乎会影响儿童哮喘的急诊就诊。急诊就诊次数的增加发生在波动后的1至2天。
