Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, China.
Regul Toxicol Pharmacol. 2010 Mar;56(2):193-6. doi: 10.1016/j.yrtph.2009.09.014. Epub 2009 Sep 27.
To perform pharmacokinetic study of melamine in rhesus monkey, melamine was orally administered to three experimental monkeys at a single dose of 1.4 mg/kg body weight. Plasma and urine were collected for the determination of melamine and cyanuric acid with a liquid chromatography tandem mass spectrometry method. The mean+/-SD area under the concentration-time curve from time zero to 48 h (AUC0-t) was 14,145+/-2002 microg/Lh. The maximum concentration of melamine in plasma (C(max)) was 1767+/-252 microg/L. The time to maximum concentration (T(max)) was 2.67+/-1.16 h and the half-life of melamine in plasma (t(1/2)) was 4.41+/-0.43 h. Following oral administration, melamine was rapidly excreted, mainly through urinary clearance. No significant correlation was found between melamine and cyanuric acid, suggesting that cyanuric acid may not be derived from melamine.
为了进行猕猴体内三聚氰胺的药代动力学研究，将 1.4mg/kg 体重的三聚氰胺单次给予 3 只实验猕猴口服。采用液相色谱-串联质谱法测定血浆和尿液中的三聚氰胺和三聚氰酸。自零时到 48 小时的浓度-时间曲线下面积（AUC0-t）的平均值±标准差为 14145±2002μg/L·h。血浆中三聚氰胺的最大浓度（Cmax）为 1767±252μg/L。达峰时间（Tmax）为 2.67±1.16h，血浆中三聚氰胺的半衰期（t1/2）为 4.41±0.43h。口服给予三聚氰胺后，其迅速排泄，主要通过尿清除。未发现三聚氰胺与三聚氰酸之间存在显著相关性，提示三聚氰酸可能不是来源于三聚氰胺。
