1 型糖尿病中的蛋白质和能量代谢。
Protein and energy metabolism in type 1 diabetes.
机构信息
Mayo Clinic, 200 First St. SW, Joseph 5-194, Rochester, MN 55905, USA.
出版信息
Clin Nutr. 2010 Feb;29(1):13-7. doi: 10.1016/j.clnu.2009.09.001. Epub 2009 Sep 27.
Abstract
Profound metabolic changes occur in people with type 1 diabetes mellitus during insulin deprivation. These include an increase in basal energy expenditure and reduced mitochondrial function. In addition, protein metabolism is significantly affected during insulin deprivation. A greater increase in whole-body protein breakdown than protein synthesis occurs resulting in a net protein loss. During insulin deprivation the splanchnic bed has a net protein accretion which accounts for the total increase in whole-body protein synthesis while muscle is in a net catabolic state.
摘要
1 型糖尿病患者在胰岛素缺乏时会发生深刻的代谢变化。这些变化包括基础能量消耗增加和线粒体功能降低。此外，胰岛素缺乏还会显著影响蛋白质代谢。全身蛋白质分解的增加大于蛋白质合成，导致净蛋白质丢失。在胰岛素缺乏期间，内脏床有净蛋白质积累，这解释了全身蛋白质合成的总增加，而肌肉处于净分解状态。
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