Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, AT-1095, Vienna, Austria.
Vaccine. 2009 Nov 23;27(50):7021-6. doi: 10.1016/j.vaccine.2009.09.069. Epub 2009 Sep 27.
Tick-borne encephalitis (TBE) virus is an important human pathogenic flavivirus that is endemic in Europe and Asia. The disease can be effectively prevented by inactivated vaccines and vaccination breakthroughs (VBTs) are rare. We investigated the characteristics of antibody responses in such VBTs in comparison to those in unvaccinated TBE patients. In contrast to the unvaccinated controls, most of the VBTs displayed a delayed IgM antibody response and had high avidity and strongly neutralizing antibodies already in the first sample taken upon hospitalization. The antibody profile of these patients therefore had the characteristics of an anamnestic immune response. In the VBTs analyzed, immunological priming and memory were apparently not sufficient or fast enough to prevent the disease.
蜱传脑炎（TBE）病毒是一种重要的人类致病性黄病毒，在欧洲和亚洲流行。该疾病可以通过灭活疫苗有效预防，且疫苗突破性感染（VBT）较为罕见。我们研究了 VBT 与未接种疫苗的 TBE 患者相比，抗体反应的特点。与未接种疫苗的对照组相比，大多数 VBT 显示出延迟的 IgM 抗体反应，并且在住院时首次采集的样本中已经具有高亲和力和强中和抗体。因此，这些患者的抗体谱具有回忆性免疫反应的特征。在分析的 VBT 中，免疫原性和记忆显然不够或不够快，无法预防疾病。
