Department of Radiology, Leiden University Medical Center, C3-Q, PO Box 9600, 2300 RC Leiden, The Netherlands.
Radiology. 2009 Dec;253(3):788-96. doi: 10.1148/radiol.2533090490. Epub 2009 Sep 29.
To explore the ability of whole-body 7.0-T magnetic resonance (MR) imaging to depict differences in aspects of the cerebral cortex of postmortem human brain specimens with cerebral amyloid beta deposition in connection with Alzheimer disease (AD), Down syndrome, or sporadic or hereditary cerebral amyloid angiopathy (CAA) and control brain specimens lacking such deposition.
This study was approved by the local institutional review board. In all cases, informed consent was obtained to perform autopsy and to use the tissues for research purposes. T2- and T2*-weighted MR imaging was performed in formalin-fixed samples of brain tissue from six subjects with AD changes, seven with CAA, and five subjects without immunohistochemical evidence of cerebral amyloid beta deposition. All MR images were visually assessed for hypointense foci in and inhomogeneity of the cortex. Sensitivity, specificity, and kappa values of these MR imaging features in the detection of histologic changes were calculated.
High-spatial-resolution 0.3 x 0.3 x 0.3-mm three-dimensional T2*-weighted images revealed hypointense foci, inhomogeneity of the cortex, or both in all specimens with brain amyloid beta deposition. These MR imaging features were observed in none of the control specimens.
The finding of postmortem susceptibility-weighted changes in the cerebral cortex of patients with cerebral amyloidosis with a human 7.0-T MR imaging system opens up the possibility of obtaining in vivo radiologic evidence of cerebral amyloid beta deposition.
探索全身 7.0-T 磁共振（MR）成像在描绘与阿尔茨海默病（AD）、唐氏综合征、散发性或遗传性脑淀粉样血管病（CAA）相关的脑淀粉样 β 沉积的人脑尸检标本大脑皮质方面差异的能力，以及缺乏此类沉积的对照脑标本。
本研究经当地机构审查委员会批准。在所有情况下，均获得了进行尸检和为研究目的使用组织的知情同意。对来自 6 名 AD 改变患者、7 名 CAA 患者和 5 名无脑淀粉样 β 沉积免疫组织化学证据的患者的福尔马林固定脑组织样本进行 T2-和 T2*-加权 MR 成像。所有 MR 图像均进行视觉评估，以评估皮质内的低信号焦点和皮质不均匀性。计算这些 MR 成像特征在检测组织学变化中的敏感性、特异性和kappa 值。
高空间分辨率 0.3 x 0.3 x 0.3-mm 三维 T2*-加权图像显示，所有脑淀粉样 β 沉积患者的标本均存在皮质内低信号焦点、皮质不均匀或两者兼有。这些 MR 成像特征在对照标本中均未观察到。
在 7.0-T 磁共振成像系统中，对脑淀粉样变性患者死后大脑皮质的磁化率加权变化的发现，为获得脑淀粉样 β 沉积的体内放射学证据提供了可能。
