Barisano Giuseppe, Sepehrband Farshid, Ma Samantha, Jann Kay, Cabeen Ryan, Wang Danny J, Toga Arthur W, Law Meng
1 Department of Radiology, Keck Medical Center of University of Southern California , Los Angeles, CA , USA.
2 Stevens Neuroimaging and Informatics Institute, University of Southern California , Los Angeles, CA , USA.
Br J Radiol. 2019 Feb;92(1094):20180492. doi: 10.1259/bjr.20180492. Epub 2018 Nov 1.
In recent years, ultra-high field MRI (7 T and above) has received more interest for clinical imaging. Indeed, a number of studies have shown the benefits from the application of this powerful tool not only for research purposes, but also in realms of improved diagnostics and patient management. The increased signal-to-noise ratio and higher spatial resolution compared with conventional and high-field clinical scanners allow imaging of small anatomical detail and subtle pathological findings. Furthermore, greater spectral resolution achieved at ultra-high field allows the resolution of metabolites for MR spectroscopic imaging. All these advantages have a significant impact on many neurological diseases, including multiple sclerosis, cerebrovascular disease, brain tumors, epilepsy and neurodegenerative diseases, in part because the pathology can be subtle and lesions small in these diseases, therefore having higher signal and resolution will help lesion detection. In this review, we discuss the main clinical neurological applications and some technical challenges which remain with ultra-high field MRI.
近年来，超高场磁共振成像（7T及以上）在临床成像方面受到了更多关注。事实上，多项研究表明，应用这一强大工具不仅在研究领域有益，而且在改善诊断和患者管理方面也有诸多益处。与传统和高场临床扫描仪相比，其信噪比的提高和空间分辨率的提升使得能够对微小的解剖细节和细微的病理发现进行成像。此外，在超高场实现的更高光谱分辨率使得能够对磁共振波谱成像中的代谢物进行分辨。所有这些优势对许多神经系统疾病都有重大影响，包括多发性硬化症、脑血管疾病、脑肿瘤、癫痫和神经退行性疾病，部分原因在于这些疾病的病理可能很细微且病变较小，因此更高的信号和分辨率将有助于病变检测。在这篇综述中，我们讨论了超高场磁共振成像的主要临床神经学应用以及仍然存在的一些技术挑战。
