巴基斯坦人群中ABO血型与青光眼的关联。

Association of ABO blood groups with glaucoma in the Pakistani population.

作者信息

Khan Muhammad Imran, Micheal Shazia, Akhtar Farah, Naveed Akhtar, Ahmed Asifa, Qamar Raheel

机构信息

Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.

出版信息

Can J Ophthalmol. 2009 Oct;44(5):582-6. doi: 10.3129/i09-104.

DOI:10.3129/i09-104

PMID:19789596

Abstract

OBJECTIVE

To study the association of blood groups with different types of glaucoma including primary open-angle glaucoma (POAG), primary closed-angle glaucoma (PCAG), and pseudoexfoliative glaucoma (PEXG) in the Pakistani population.

STUDY DESIGN

The present study was a prospective case control study.

PARTICIPANTS

ABO and Rh blood groups were analyzed in 2046 controls and 477 glaucoma patients (220 POAG, 146 PCAG, and 111 PEXG).

METHODS

Hemagglutination patterns were used to determine the prevalence of the ABO and Rh blood groups in all the subjects. Logistic regression analysis was carried out to evaluate any association of the different blood groups with glaucoma.

RESULTS

In the present study, the percentage of blood groups A, B, AB, and O in patients was found to be 19%, 41%, 10%, and 30%, and in the control group, the values were 26%, 31%, 12%, and 31%, respectively. A significant positive association was found between the B blood group and glaucoma (p value < 0.05, odds ratio [OR] 1.5, and c2 15.8). Logistic regression analysis revealed that the blood group B was associated with all types of glaucoma with OR of 1.35 (95% CI 1.01-1.80; p = 0.04) for POAG, 1.71 (95% CI 1.21-2.40; p = 0.002) for PCAG, and 1.61 (95% CI 1.09-2.36; p = 0.016) for PEXG. POAG was also found to be associated with the Rh- allele (p < 0.05) with an OR of 4.05 (95% CI 2.98-5.51), as compared with controls.

CONCLUSIONS

In the Pakistani patient cohort, blood group B is associated with all types of glaucoma and the Rhallele is associated only with POAG.

摘要

目的

研究巴基斯坦人群中血型与不同类型青光眼（包括原发性开角型青光眼（POAG）、原发性闭角型青光眼（PCAG）和剥脱性青光眼（PEXG））之间的关联。

研究设计

本研究为前瞻性病例对照研究。

参与者

对2046名对照者和477名青光眼患者（220例POAG、146例PCAG和111例PEXG）的ABO和Rh血型进行了分析。

方法

采用血凝模式确定所有受试者中ABO和Rh血型的患病率。进行逻辑回归分析以评估不同血型与青光眼之间的任何关联。

结果

在本研究中，患者中A、B、AB和O血型的百分比分别为19%、41%、10%和30%，而在对照组中，这些值分别为26%、31%、12%和31%。发现B血型与青光眼之间存在显著正相关（p值<0.05，比值比[OR]为1.5，卡方值为15.8）。逻辑回归分析显示，B血型与所有类型的青光眼相关，POAG的OR为1.35（95%可信区间1.01-1.80；p = 0.04），PCAG的OR为1.71（95%可信区间1.21-2.40；p = 0.002），PEXG的OR为1.61（95%可信区间1.09-2.36；p = 0.016）。与对照组相比，还发现POAG与Rh-等位基因相关（p < 0.05），OR为4.05（95%可信区间2.98-5.51）。