Goldsher M, Bartal A, Eliachar I, Robinson E
Arch Otolaryngol. 1977 Sep;103(9):550-2. doi: 10.1001/archotol.1977.00780260080012.
Four malignant tumors and one benign in a 76-year-old man appeared. Three of the neoplasms were in the respiratory system, and one was a bladder carcinoma; all were linked to heavy smoking habits. The patient underwent immunologic investigations consisting of in vivo testing for cutaneous reactivity, in vitro lymphocyte blastogenesis studies, T- and B-cell level studies, and serum immunoglobulin level studies. The studies have demonstrated anergy to recall antigens, decreased lymphocyte responses to phytohemagglutinin, and low levels of peripheral T-lymphocytes. The serum immunoglobulins were at the upper limit of the normal. The relationship between the patient's immunologic status and the occurrence of multiple primary neoplasms is discussed.
一名76岁男性身上出现了4个恶性肿瘤和1个良性肿瘤。其中3个肿瘤位于呼吸系统，1个是膀胱癌；所有这些肿瘤都与重度吸烟习惯有关。该患者接受了免疫检查，包括体内皮肤反应性测试、体外淋巴细胞增殖研究、T细胞和B细胞水平研究以及血清免疫球蛋白水平研究。这些研究显示对回忆抗原无反应、淋巴细胞对植物血凝素的反应降低以及外周T淋巴细胞水平较低。血清免疫球蛋白处于正常范围的上限。讨论了患者免疫状态与多发性原发性肿瘤发生之间的关系。
