Goldsher M, Eliachar I, Mekori T, Robinson E
Ann Otol Rhinol Laryngol. 1979 May-Jun;88(3 Pt 1):311-5. doi: 10.1177/000348947908800302.
Eleven patients with laryngeal cancer associated with additional primary tumors underwent cutaneous delayed hypersensitivity tests and lymphocyte stimulation studies with phytohemagglutinin for evaluation of their cellular immunity. Five of the 11 patients were anergic or hypoergic as shown by skin tests to recall antigens and seven of nine patients had impaired lymphocyte transformation. Depressed immunity was more often observed in patients with an active malignancy. The level of serum immunoglobulins was elevated in two of eight studied patients, and in the remaining patients was within the normal range. All patients had a history of excessive smoking. Most frequently, second tumors were found in the lung, urinary tract and skin. The prognosis seemed to be determined by the additional tumor rather than by the laryngeal cancer.
11例喉癌合并其他原发性肿瘤的患者接受了皮肤迟发型超敏反应试验和用植物血凝素进行的淋巴细胞刺激研究，以评估其细胞免疫功能。11例患者中有5例对回忆抗原的皮肤试验显示无反应或反应低下，9例患者中有7例淋巴细胞转化受损。免疫功能低下在患有活动性恶性肿瘤的患者中更常观察到。8例研究患者中有2例血清免疫球蛋白水平升高，其余患者在正常范围内。所有患者都有大量吸烟史。最常见的是，第二肿瘤发生在肺、泌尿道和皮肤。预后似乎由附加肿瘤而非喉癌决定。
