Manns Joseph R, Eichenbaum Howard
Department of Psychology, Emory University, Atlanta, Georgia 30322, USA.
Learn Mem. 2009 Sep 30;16(10):616-24. doi: 10.1101/lm.1484509. Print 2009 Oct.
The hippocampus has been proposed to support a cognitive map, a mental representation of the spatial layout of an environment as well as the nonspatial items encountered in that environment. In the present study, we recorded simultaneously from 43 to 61 hippocampal pyramidal cells as rats performed an object recognition memory task in which novel and repeated objects were encountered in different locations on a circular track. Multivariate analyses of the neural data indicated that information about object identity was represented secondarily to the primary information dimension of object location. In addition, the neural data related to performance on the recognition memory task. The results suggested that objects were represented as points of interest on the hippocampal cognitive map and that this map was useful in remembering encounters with particular objects in specific locations.
海马体被认为支持认知地图，即对环境空间布局以及在该环境中遇到的非空间项目的心理表征。在本研究中，当大鼠执行物体识别记忆任务时，我们同时记录了43至61个海马锥体神经元，在该任务中，新奇和重复的物体出现在圆形轨道的不同位置。对神经数据的多变量分析表明，关于物体身份的信息在表征上仅次于物体位置这一主要信息维度。此外，神经数据与识别记忆任务的表现相关。结果表明，物体在海马认知地图上被表征为兴趣点，并且这张地图有助于记住在特定位置遇到的特定物体。
