Tambs Kristian, Czajkowsky Nikolai, Røysamb Espen, Neale Michael C, Reichborn-Kjennerud Ted, Aggen Steven H, Harris Jennifer R, Ørstavik Ragnhild E, Kendler Kenneth S
Department of Mental Health, Norwegian Institute of Public Health, Box 4404 Nydalen, 0403 Oslo 3, Norway.
Br J Psychiatry. 2009 Oct;195(4):301-7. doi: 10.1192/bjp.bp.108.059485.
Twin data permit decomposition of comorbidity into genetically and environmentally derived correlations. No previous twin study includes all major forms of anxiety disorder.
To estimate the degree to which genetic and environmental risk factors are shared rather than unique to dimensionally scored panic disorder, generalised anxiety disorder, phobias, obsessive-compulsive disorder and post-traumatic stress disorder.
Data obtained from 2801 young-adult Norwegian twins by means of the Composite International Diagnostic Interview were analysed with the Mx program.
A multivariate common factor model fitted best. The latent liability to all anxiety disorders was substantially more heritable (54%) than the individual disorders (23% to 40%). Most of the genetic effect was common to the disorders. Genes contributed just over 50% to the covariance between liabilities.
The five anxiety disorders all share genetic and environmental risk factors. This has implications for the revision of the anxiety disorder section in DSM-V.
双胞胎数据有助于将共病现象分解为遗传和环境因素导致的相关性。之前没有双胞胎研究涵盖所有主要形式的焦虑症。
评估遗传和环境风险因素在维度评分的惊恐障碍、广泛性焦虑症、恐惧症、强迫症和创伤后应激障碍中是共同存在还是各自独有的程度。
通过综合国际诊断访谈从2801名挪威年轻成人双胞胎中获取的数据，使用Mx程序进行分析。
多变量共同因素模型拟合效果最佳。所有焦虑症的潜在易感性遗传性（54%）远高于个体疾病（23%至40%）。大多数遗传效应在这些疾病中是共同的。基因对易感性之间的协方差贡献略超过50%。
这五种焦虑症都共享遗传和环境风险因素。这对《精神疾病诊断与统计手册》第五版中焦虑症部分的修订有影响。
