Nabipour I, Ebrahimi A, Jafari S M, Vahdat K, Assadi M, Movahed A, Moradhaseli F, Obeidi N, Sanjdideh Z
Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, I.R. Iran.
J Endocrinol Invest. 2009 May;32(5):406-10. doi: 10.1007/BF03346476.
It is uncertain whether homocysteine and the metabolic syndrome or its components are related in the general population, as studies investigating the association between homocysteine levels and insulin resistance have shown conflicting results.
In an ancillary study to the Persian Gulf Healthy Heart Study, a cohort study of Iranian men and women aged >or=25 yr, a random sample of 1754 subjects were evaluated for the association of plasma homocysteine levels and the metabolic syndrome using National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP)-III criteria. Total homocysteine levels and high sensitivity C-reactive protein (CRP) were determined by enzyme-linked immunosorbent assays.
Subjects with lower HDL-cholesterol and higher blood pressure showed significantly higher homocysteine levels (p=0.001 and p<0.0001; respectively). There was no significant difference in serum levels of homocysteine between subjects with and without the metabolic syndrome. In multiple logistic regression analysis, the metabolic syndrome did not show a significant association with serum homocysteine levels after adjusting for sex, age, smoking, fruit and vegetable intake pattern, body mass index, and physical inactivity. Concurrent elevated CRP levels and the metabolic syndrome also did not show a significant association with serum homocysteine levels after adjusting for sex, age, and lifestyle cardiovascular risk factors.
There was no association between the metabolic syndrome using NCEP-ATPIII criteria and homocysteinemia in this study. These data refute the hypothesis that homocysteine levels are influenced by the metabolic syndrome, at least in general healthy population.
在普通人群中，同型半胱氨酸与代谢综合征或其组分之间是否存在关联尚不确定，因为调查同型半胱氨酸水平与胰岛素抵抗之间关联的研究结果相互矛盾。
在波斯湾健康心脏研究的一项辅助研究中，该研究是对年龄≥25岁的伊朗男性和女性进行的队列研究，使用美国国家胆固醇教育计划（NCEP）成人治疗小组（ATP）III标准，对1754名受试者的随机样本进行血浆同型半胱氨酸水平与代谢综合征关联的评估。通过酶联免疫吸附测定法测定总同型半胱氨酸水平和高敏C反应蛋白（CRP）。
高密度脂蛋白胆固醇水平较低和血压较高的受试者同型半胱氨酸水平显著更高（分别为p = 0.001和p < 0.0001）。患有和未患有代谢综合征的受试者之间血清同型半胱氨酸水平无显著差异。在多因素逻辑回归分析中，在调整性别、年龄、吸烟、水果和蔬菜摄入模式、体重指数和身体活动不足后，代谢综合征与血清同型半胱氨酸水平未显示出显著关联。在调整性别、年龄和生活方式心血管危险因素后，同时升高的CRP水平和代谢综合征与血清同型半胱氨酸水平也未显示出显著关联。
本研究中使用NCEP-ATPIII标准的代谢综合征与高同型半胱氨酸血症之间无关联。这些数据反驳了同型半胱氨酸水平受代谢综合征影响的假设，至少在一般健康人群中如此。
