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脊髓手术后患者的皮质活动与手部功能恢复

Cortical activity and hand function restoration in a patient after spinal cord surgery.

作者信息

Carlstedt Thomas, Hultgren Tomas, Nyman Torbjörn, Hansson Thomas

机构信息

The PNI-Unit, The Royal National Orthopaedic Hospital, Stanmore, UK.

出版信息

Nat Rev Neurol. 2009 Oct;5(10):571-4. doi: 10.1038/nrneurol.2009.137.

DOI:10.1038/nrneurol.2009.137
PMID:19794515
Abstract

BACKGROUND

Following a motorcycle accident, a 9-year-old boy experienced a complete right-sided (dominant) arm and hand paralysis with total sensory loss, Horner syndrome and severe constant pain. This study assessed the long-term outcome of spinal cord surgery undertaken on the patient, focusing on the restored hand function and related cortical activity. The study follows on from previous reports on the same patient.

INVESTIGATIONS

Clinical functional and electrophysiological examinations. Functional MRI of cortical activity.

DIAGNOSIS

Complete brachial plexus (C5-T1) avulsion from the spinal cord.

MANAGEMENT

Spinal cord surgery to restore motor trajectories.

摘要

背景

一名9岁男孩在摩托车事故后，右侧（优势侧）手臂和手部完全瘫痪，伴有完全感觉丧失、霍纳综合征和严重的持续性疼痛。本研究评估了对该患者进行脊髓手术的长期结果，重点关注恢复的手部功能和相关的皮质活动。该研究延续了之前对同一患者的报道。

调查

临床功能和电生理检查。皮质活动的功能磁共振成像。

诊断

臂丛神经（C5-T1）从脊髓完全撕脱。

治疗

脊髓手术以恢复运动轨迹。

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1
Cortical activity and hand function restoration in a patient after spinal cord surgery.脊髓手术后患者的皮质活动与手部功能恢复
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2
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bioRxiv. 2023 Nov 1:2023.07.19.549746. doi: 10.1101/2023.07.19.549746.
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Horner's syndrome secondary to T1-T2 intervertebral disc prolapse.继发于T1-T2椎间盘突出的霍纳综合征

本文引用的文献

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Cortical excitation and chronic pain.皮质兴奋与慢性疼痛。
Trends Neurosci. 2008 Apr;31(4):199-207. doi: 10.1016/j.tins.2008.01.003. Epub 2008 Mar 7.
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Cell death after dorsal root injury.背根损伤后的细胞死亡。
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Karolinska institutet 200-year anniversary. Symposium on traumatic injuries in the nervous system: injuries to the spinal cord and peripheral nervous system - injuries and repair, pain problems, lesions to brachial plexus.卡罗琳斯卡学院200周年校庆。神经系统创伤研讨会：脊髓和周围神经系统损伤——损伤与修复、疼痛问题、臂丛神经损伤。
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On acute gene expression changes after ventral root replantation.关于腹侧神经根再植后的急性基因表达变化。
Front Neurol. 2011 Jan 4;1:159. doi: 10.3389/fneur.2010.00159. eCollection 2011.
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Perspectives on the treatment of the longitudinal spinal cord injury.脊髓纵向损伤的治疗观点
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Pain phenomena and sensory recovery following brachial plexus avulsion injury and surgical repairs.臂丛神经撕脱伤及手术修复后的疼痛现象与感觉恢复
J Hand Surg Br. 2006 Dec;31(6):596-605. doi: 10.1016/j.jhsb.2006.04.027. Epub 2006 Jul 5.
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A single re-implanted ventral root exerts neurotropic effects over multiple spinal cord segments in the adult rat.在成年大鼠中，单一重新植入的腹根对多个脊髓节段发挥神经营养作用。
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