Carlstedt Thomas
Department of Clinical Science and Education, Hand Surgery, Karolinska Institute, Södersjukhusetc Stockholm, Sweden.
Front Neurol. 2010 Jul 12;1:11. doi: 10.3389/fneur.2010.00011. eCollection 2010.
The current technique for surgical treatment of the longitudinal spinal cord injury has proven to be successful for restoration of some motor function and alleviation of pain. This has been the first step in finding a cure for spinal cord injuries, but so far there are many obstacles still to be overcome. In this particular injury return of function from spinal cord surgery is only partial. Some of the main remaining problems are related to injury-induced neuronal death, direction and specificity of regeneration and muscle, and receptor disintegration from long time denervation. Currently this is a surgical procedure without any adjuvant treatments. In order to gain further functional improvement combinational therapies developed in basic science experiments are essential.
目前用于治疗脊髓纵向损伤的外科技术已被证明在恢复某些运动功能和减轻疼痛方面是成功的。这是找到脊髓损伤治疗方法的第一步，但到目前为止仍有许多障碍有待克服。在这种特定损伤中，脊髓手术带来的功能恢复只是部分的。一些主要的遗留问题与损伤诱导的神经元死亡、再生的方向和特异性以及肌肉有关，还有长时间去神经支配导致的受体解体。目前这是一种没有任何辅助治疗的外科手术。为了获得进一步的功能改善，基础科学实验中开发的联合疗法至关重要。
