Carlstedt Thomas
Wolfson CARD, Kings College London , London , UK.
Front Neurol. 2016 Aug 23;7:135. doi: 10.3389/fneur.2016.00135. eCollection 2016.
Further progress in the treatment of the longitudinal spinal cord injury has been made. In an inverted translational study, it has been demonstrated that return of sensory function can be achieved by bypassing the avulsed dorsal root ganglion neurons. Dendritic growth from spinal cord sensory neurons could replace dorsal root ganglion axons and re-establish a reflex arch. Another research avenue has led to the development of adjuvant therapy for regeneration following dorsal root to spinal cord implantation in root avulsion injury. A small, lipophilic molecule that can be given orally acts on the retinoic acid receptor system as an agonist. Upregulation of dorsal root ganglion regenerative ability and organization of glia reaction to injury were demonstrated in treated animals. The dual effect of this substance may open new avenues for the treatment of root avulsion and spinal cord injuries.
在脊髓纵向损伤的治疗方面已取得进一步进展。在一项反向转化研究中，已证明通过绕过撕脱的背根神经节神经元可实现感觉功能的恢复。脊髓感觉神经元的树突生长可替代背根神经节轴突并重新建立反射弧。另一条研究途径已促成在神经根撕脱伤中背根植入脊髓后再生辅助治疗的发展。一种可口服的亲脂性小分子作为激动剂作用于视黄酸受体系统。在接受治疗的动物中，已证明背根神经节再生能力上调以及胶质细胞对损伤的反应得到组织化。这种物质的双重作用可能为神经根撕脱和脊髓损伤的治疗开辟新途径。
