Clinical Science at South Bristol, University of Bristol, Level 7 CSSB, Bristol Royal Infirmary, Upper Maudlin Street, Bristol, UK, BS2 8HW.
J Gastrointestin Liver Dis. 2009 Sep;18(3):337-43.
The assessment of disease activity in various conditions may be performed using a range of different techniques. These include the use of non-invasive tests, such as acute phase inflammatory markers and simple radiological techniques, to more advanced invasive and complex modalities. Over the past two decades the analysis of volatile organic compounds (VOCs) in biological specimens has attracted a considerable amount of clinical interest. The investigation of VOCs, using a variety of analytical techniques, has shown a significant correlation between the pattern and concentration of VOCs and the occurrence of various diseases. This provides a potentially non-invasive means of diagnosis, monitoring of pathological processes and assessment of pharmacological response. It may be rapid, simple and acceptable to patients. In this paper we review the medical literature and research efforts that have been carried out over the past decades, and try to summarize the clinical implications of VOC analysis of various biological emanations including stool, breath and blood samples and their correlation with gastrointestinal and liver diseases.
在各种情况下，疾病活动的评估可以使用多种不同的技术进行。这些技术包括使用非侵入性测试，如急性期炎症标志物和简单的放射学技术，以及更先进的侵入性和复杂的方式。在过去的二十年中，对生物标本中挥发性有机化合物（VOC）的分析引起了相当多的临床关注。使用各种分析技术对 VOC 进行分析，显示出 VOC 的模式和浓度与各种疾病的发生之间存在显著相关性。这为诊断、病理过程监测和药物反应评估提供了一种潜在的非侵入性手段。它可能快速、简单且易于被患者接受。本文综述了过去几十年中进行的医学文献和研究工作，并试图总结各种生物排放物（包括粪便、呼吸和血液样本）中 VOC 分析的临床意义及其与胃肠道和肝脏疾病的相关性。
