Department of Nutrition and Food Hygiene, Peking University, Beijing, 100083, China.
Bull Environ Contam Toxicol. 2010 Jan;84(1):39-45. doi: 10.1007/s00128-009-9884-4. Epub 2009 Oct 1.
Cytostatic drugs are used in cancer therapy. They can enter hospital wastewater due to excretion by patients undergoing chemotherapy. Little attention has been paid to these drugs in China even though their usage is high. The effluents of 21 hospitals of different size in Beijing, China, were investigated on 1-7 different days. Nine cytostatic compounds (methotrexate, azathioprine, doxorubicin, doxorubicinol, vincristine, ifosfamide, cyclophosphamide, etoposide, and procarbazine) were tested. Of the 65 effluent samples analyzed, the median concentrations for methotrexate, azathioprine, ifosfamide, cyclophosphamide and etoposide were 17, 15, 151, 100 and 42 ng/L, respectively. Doxorubicin, doxorubicinol, vincristine and procarbazine were not detected in this study. These results suggested that the hospital effluents are an important source of certain cytostatic drugs in aqueous environment.
细胞抑制剂类药物被应用于癌症治疗。由于接受化疗的患者会将其排泄到体内，因此它们可能会进入医院废水中。尽管中国此类药物的使用量很高，但对这些药物的关注却很少。本研究调查了中国北京 21 家不同规模医院的废水，共在 1-7 天内采集了 65 个废水样本。检测了 9 种细胞抑制剂类化合物（甲氨蝶呤、巯嘌呤、阿霉素、阿霉素醇、长春新碱、异环磷酰胺、环磷酰胺、依托泊苷和丙卡巴肼）。在分析的 65 个废水样本中，甲氨蝶呤、巯嘌呤、异环磷酰胺、环磷酰胺和依托泊苷的中位数浓度分别为 17、15、151、100 和 42ng/L。本研究中未检测到阿霉素、阿霉素醇、长春新碱和丙卡巴肼。这些结果表明，医院废水是水环境中某些细胞抑制剂类药物的重要来源。
