Mustafa Degirmenci, Ibrahim Bulduk, Erten Akbel
Tepecik Training and Research Hospital, Medical Oncology Department, Health Sciences University, Izmir, Turkey.
Department of Chemical Engineering, Faculty of Engineering, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Sci Rep. 2024 Aug 1;14(1):17765. doi: 10.1038/s41598-024-68666-3.
Pazopanib, which is dangerous for aquatic environments due to its toxic and bioaccumulation potential, has been detected at different concentrations in oncology hospital wastewater, sewage, and surface waters. This study aimed to remove pazopanib from wastewater by activated carbon adsorption technique. The effect of the main variables such as initial concentration, pH of pazopanib solution, adsorbent dose, contact time of the phases, and temperature on the adsorption process was evaluated and the optimum adsorption conditions were determined. The experimental data were applied to Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich adsorption isotherm models to describe the adsorption behavior. The experimental data were applied to pseudo-first-order, pseudo-second-order, and intra-particle diffusion kinetic models to describe the adsorption kinetics. Isotherms were established in the 20-50 °C temperature range to study the adsorption equilibrium. According to the results, the highest removal efficiency of pazopanib (95.87%) was obtained at initial concentration (100 mg L), adsorbent dose (0.30 g L), temperature (20 °C), contact time (120 min) and pH (7.0). The adsorption kinetics was well described by the pseudo-second-order kinetic model (R = 0.9998) and the adsorption isotherm by the Langmuir model (R = 0.9999). In thermodynamic studies, the negative values of standard enthalpy (ΔH°), standard free enthalpy (ΔG°), and free entropy (ΔS°) indicate that the adsorption process is spontaneous and favorable, i.e. the disorder is reduced. These results indicate that the developed adsorption process can be efficiently and spontaneously applied for the removal of pazopanib from aqueous solutions.
帕唑帕尼因其潜在的毒性和生物累积性而对水生环境有害，已在肿瘤医院废水、污水和地表水中检测到不同浓度的该物质。本研究旨在通过活性炭吸附技术去除废水中的帕唑帕尼。评估了初始浓度、帕唑帕尼溶液的pH值、吸附剂剂量、各相接触时间和温度等主要变量对吸附过程的影响，并确定了最佳吸附条件。将实验数据应用于朗缪尔、弗伦德利希、坦金和杜比宁-拉杜舍维奇吸附等温线模型来描述吸附行为。将实验数据应用于准一级、准二级和颗粒内扩散动力学模型来描述吸附动力学。在20-50°C温度范围内建立等温线以研究吸附平衡。结果表明，在初始浓度（100 mg/L）、吸附剂剂量（0.30 g/L）、温度（20°C）、接触时间（120分钟）和pH值（7.0）条件下，帕唑帕尼的去除效率最高（95.87%）。吸附动力学用准二级动力学模型（R = 0.9998）能很好地描述，吸附等温线用朗缪尔模型（R = 0.9999）能很好地描述。在热力学研究中，标准焓（ΔH°）、标准自由焓（ΔG°）和自由熵（ΔS°）的负值表明吸附过程是自发且有利的，即无序度降低。这些结果表明，所开发的吸附工艺可有效且自发地用于从水溶液中去除帕唑帕尼。
