Solomita Mario, Palmer Lucy B, Daroowalla Feroza, Liu Jeffrey, Miller Dori, LeBlanc Deniese S, Smaldone Gerald C
Department of Pulmonary and Critical Care Medicine, Stony Brook University Medical Center, State University of New York at Stony Brook, HSC T 17-040, Stony Brook, NY 11794, USA.
Respir Care. 2009 Oct;54(10):1329-35.
To determine potential effects of humidification on the volume of airway secretions in mechanically ventilated patients.
Water vapor delivery from devices providing non-heated-wire humidification, heated-wire humidification, and heat and moisture exchanger (HME) were quantified on the bench. Then, patients requiring 24-hour mechanical ventilation were exposed sequentially to each of these humidification devices, and secretions were removed and measured by suctioning every hour during the last 4 hours of the 24-hour study period.
In vitro water vapor delivery was greater using non-heated-wire humidification, compared to heated-wire humidification and HME. In vivo, a total of 9 patients were studied. Secretion volume following humidification by non-heated-wire humidification was significantly greater than for heated-wire humidification and HME (P=.004).
The volume of secretions appeared to be linked to humidification, as greater water vapor delivery measured in vitro was associated with greater secretion volume in vivo.
确定湿化对机械通气患者气道分泌物量的潜在影响。
在实验台上对提供非加热丝湿化、加热丝湿化和热湿交换器（HME）的设备的水汽输送量进行量化。然后，对需要24小时机械通气的患者依次使用这些湿化设备，在24小时研究期的最后4小时内，每小时通过抽吸清除并测量分泌物。
与加热丝湿化和热湿交换器相比，使用非加热丝湿化时体外水汽输送量更大。在体内，共研究了9例患者。非加热丝湿化后的分泌物量显著大于加热丝湿化和热湿交换器（P = 0.004）。
分泌物量似乎与湿化有关，因为体外测量的更大水汽输送量与体内更大的分泌物量相关。
