Popescu T A, Stef C, Moraru G, Cucuianu M P
Atherosclerosis. 1977 Jun;27(2):155-63. doi: 10.1016/0021-9150(77)90053-3.
Serum total lipids and cholesterol, electrophoretically determined lipoprotein concentrations, serum pseudocholinesterase and dilute blood clot lysis time were determined in 630 healthy subjects (287 men and 343 women) aged 20-60, working in the food industry. A high incidence of over-weight was noted ranging from 22.4% in women aged 20-40 to 58.7% in men aged 41-60. Over-weight subjects presenting higher levels of serum cholesterol, total lipids and of the pre-beta electrophoretic fraction also had a higher pseudo-cholinesterase activity and a more delayed clot lysis time than normal-weight subjects matched as to age and sex. When the material was divided into quintiles for pre-beta- and beta-lipoproteins, a highly significant delay of fibrinolysis was noted in the fourth and fifth quintiles for pre-beta-lipoproteins, but no significant changes of lysis time occurred with increasing concentrations of beta-lipoproteins. Possible explanations of the abovementioned findings are briefly discussed.
对630名年龄在20至60岁之间、从事食品行业的健康受试者（287名男性和343名女性）测定了血清总脂质和胆固醇、电泳测定的脂蛋白浓度、血清假性胆碱酯酶以及稀释血液凝块溶解时间。超重发生率较高，范围从20至40岁女性的22.4%到41至60岁男性的58.7%。与年龄和性别相匹配的正常体重受试者相比，超重受试者的血清胆固醇、总脂质以及前β电泳部分水平较高，其假性胆碱酯酶活性也较高，凝块溶解时间更延迟。当根据前β脂蛋白和β脂蛋白将材料分为五等份时，在前β脂蛋白的第四和第五等份中观察到纤维蛋白溶解明显延迟，但随着β脂蛋白浓度增加，溶解时间无显著变化。简要讨论了上述发现的可能解释。
