Institute of Hygiene and Public Health, Cluj-Napoca, Romania.
Biol Trace Elem Res. 1985 Nov;8(3):167-72. doi: 10.1007/BF02917455.
Starting from experimental observations demonstrating that a high ratio of zinc to copper led to hypercholesterolemia in rats, serum Zn and Cu levels were measured by atomic absorption spectrophotometry in 65 normolipemic controls and in 100 subjects with various types of hyperlipoproteinemia (HLP). Serum Zn levels did not significantly differ from control values in any type of HLP. However, hyperlipoproteinemic patients with obvious clinical atherosclerosis displayed significantly lower serum-Zn concentration than hyperlipo-proteinemic subjects without clinical symptoms. On the other hand, when compared to control subjects, serum Cu levels were not found to be decreased, but rather increased, in hyperlipoproteinemic patients with or without atherosclerosis. As a result, the Zn∶Cu ratio appeared to be lower than normal in hyperlipoproteinemic patients with cardiovascular disease. It is conceivable that changes of these trace elements should be rather connected to vessel injury and associated disease than to HLP which, at least in humans, is not accompanied by a high Zn∶Cu ratio.
从实验观察开始，证明高锌铜比会导致大鼠高胆固醇血症，通过原子吸收分光光度法测量了 65 名正常血脂对照者和 100 名各种类型高脂血症（HLP）患者的血清 Zn 和 Cu 水平。在任何类型的 HLP 中，血清 Zn 水平与对照值无显著差异。然而，有明显临床动脉粥样硬化的高脂蛋白血症患者的血清-Zn 浓度明显低于无症状的高脂蛋白血症患者。另一方面，与对照组相比，有或没有动脉粥样硬化的高脂蛋白血症患者的血清 Cu 水平并未降低，反而升高。因此，心血管疾病高脂蛋白血症患者的 Zn∶Cu 比值似乎低于正常水平。可以想象，这些微量元素的变化与其说是与 HLP 有关，不如说是与血管损伤和相关疾病有关，因为至少在人类中，高脂蛋白血症并不伴有高 Zn∶Cu 比值。
