Cucuianu M, Popescu T A, Opincaru A, Hărăgus S
Clin Chim Acta. 1975 Feb 22;59(1):19-27. doi: 10.1016/0009-8981(75)90213-2.
Starting from previous observations emphasizing an increased pseudocholinesterase (PCE) activity in obese and hyperlipemic subjects, the behaviour of this enzyme and of ceruloplasmin was studied in connection with changes of serum lipids and lipoproteins in various types of hyperlipoproteinemia. When compared to values detected in 67 middle-aged normal weight normolipemic subjects, PCE activity was found to be significantly greater (smaller than 0.001) in the 49 overweight subjects without obvious hyperlipemia but presenting a moderate increase of the prebeta electrophoretic fraction. PCE activity was much higher in lean or overweight subjects with endogenous hypertriglyceridemia (68 patients with type IV and 86 patients with mixed hyperlipemia). The slight increase of mean values of PCE activity in the 53 subjects with type II-a was due mainly to overweight subjects, while this enzyme's activity was not significantly changed in lean subjects with pure hypercholesterolemia. PCE activity was positively correlated with serum triglyceride (r equals 0.540; p smaller than 0.001) and the prebeta electrophoretic fraction (r equals 610; p smaller than 0.001). The correlation with beta-lipoproteins was not significant. Ceruloplasmin levels were not significantly changed. It is suggested that elevation of PCE activity could be connected to mechanisms leading to an increased secretion rate of lipoproteins.
基于先前的观察结果强调肥胖和高脂血症患者假性胆碱酯酶（PCE）活性增加，研究了该酶和铜蓝蛋白的行为与各种类型高脂蛋白血症中血脂和脂蛋白变化的关系。与67名中年正常体重血脂正常的受试者检测值相比，在49名无明显高脂血症但前β电泳分数中度增加的超重受试者中，发现PCE活性显著更高（小于0.001）。在患有内源性高甘油三酯血症的瘦或超重受试者（68名IV型患者和86名混合性高脂血症患者）中，PCE活性更高。II - a型的53名受试者中PCE活性平均值的轻微增加主要归因于超重受试者，而在单纯高胆固醇血症的瘦受试者中该酶的活性没有显著变化。PCE活性与血清甘油三酯呈正相关（r等于0.540；p小于0.001）和前β电泳分数（r等于610；p小于0.001）。与β - 脂蛋白的相关性不显著。铜蓝蛋白水平没有显著变化。有人认为PCE活性升高可能与导致脂蛋白分泌率增加的机制有关。
