Siekmann Arndt F, Standley Clive, Fogarty Kevin E, Wolfe Scot A, Lawson Nathan D
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01602, USA.
Genes Dev. 2009 Oct 1;23(19):2272-7. doi: 10.1101/gad.1813509.
The aorta traverses the body, yet little is known about how it is patterned in different anatomical locations. Here, we show that the aorta develops from genetically distinct endothelial cells originating from diverse locations within the embryo. Furthermore, chemokine (C-X-C motif) receptor 4a (cxcr4a) is restricted to endothelial cells derived from anterior mesoderm, and is required specifically for formation of the lateral aortae. Cxcl12b, a cxcr4a ligand, is expressed in endoderm underlying the lateral aortae, and loss of cxcl12b phenocopies cxcr4a deficiency. These studies reveal unexpected endothelial diversity within the aorta that is necessary to facilitate its regional patterning by local cues.
主动脉贯穿全身，但对于其在不同解剖位置的形成模式却知之甚少。在此，我们表明主动脉由源自胚胎内不同位置的基因上不同的内皮细胞发育而来。此外，趋化因子（C-X-C基序）受体4a（cxcr4a）仅限于源自前中胚层的内皮细胞，并且是形成侧主动脉所特需的。Cxcl12b，一种cxcr4a配体，在侧主动脉下方的内胚层中表达，并且cxcl12b的缺失模拟了cxcr4a缺陷的表型。这些研究揭示了主动脉内意想不到的内皮细胞多样性，这对于通过局部信号促进其区域模式形成是必要的。
