Raz Erez, Mahabaleshwar Harsha
Institute of Cell Biology, ZMBE, University of Münster, Von-Esmarch-Strasse 56, 48149 Münster, Germany.
Development. 2009 Apr;136(8):1223-9. doi: 10.1242/dev.022418.
Chemokines and their receptors were discovered about twenty years ago as mediators of leukocyte traffic. Over the past decade, functional studies of these molecules have revealed their importance for cell migration processes during embryogenesis, which, in addition to providing mechanistic insights into embryonic development, could complement information about chemokine function in the immune system. Here, we review the roles of the chemokine stromal cell-derived factor 1 (SDF-1/CXCL12) and its receptor CXCR4 during zebrafish and mouse embryonic development, and discuss their function in regulating the interactions of cells with their extracellular environment, in directing their migration, and in maintaining their location.
趋化因子及其受体约在二十年前作为白细胞迁移的介质被发现。在过去十年中，对这些分子的功能研究揭示了它们在胚胎发育过程中对细胞迁移过程的重要性，这除了能为胚胎发育提供机制性见解外，还可补充有关趋化因子在免疫系统中功能的信息。在此，我们综述趋化因子基质细胞衍生因子1（SDF-1/CXCL12）及其受体CXCR4在斑马鱼和小鼠胚胎发育过程中的作用，并讨论它们在调节细胞与其细胞外环境的相互作用、指导细胞迁移以及维持细胞位置方面的功能。
