Sturgess R P, Macartney J C, Makgoba M W, Hung C H, Haskard D O, Ciclitira P J
Division of Pharmacology, Rayne Institute, UMDS, St Thomas's Hospital, London, UK.
Clin Exp Immunol. 1990 Dec;82(3):489-92. doi: 10.1111/j.1365-2249.1990.tb05477.x.
The expression of intercellular adhesion molecule-1 (ICAM-1) was studied on peroral jejunal biopsies from patients with coeliac disease. The biopsies from untreated patients exhibited greater staining of the superficial lamina propria cells compared with treated patients and controls. A gluten challenge in treated patients produced an altered staining pattern within 2 h. The results demonstrate the role of ICAM-1 expression in coeliac disease, providing further evidence for the role of lamina propria cells in the pathogenesis of this condition.
对乳糜泻患者的经口空肠活检组织进行了细胞间黏附分子-1（ICAM-1）表达的研究。与接受治疗的患者及对照组相比，未经治疗患者的活检组织中，固有层浅层细胞染色更深。接受治疗的患者进行麸质激发试验后，2小时内染色模式发生改变。这些结果证明了ICAM-1表达在乳糜泻中的作用，为固有层细胞在该病发病机制中的作用提供了进一步证据。
