Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
Int J Dermatol. 2010 Feb;49(2):146-8. doi: 10.1111/j.1365-4632.2009.04238.x. Epub 2009 Oct 1.
There is ample evidence for involvement of macrophage migration inhibitory factor (MIF) in autoimmune and inflammatory diseases.
The aim of this study was to determine whether MIF levels were raised in the sera of patients with pemphigus vulgaris (PV).
Serum MIF levels were measured using ELISA method in 22 patients with active PV and 21 age- and sex-matched healthy controls and the results were compared with each other.
The mean serum MIF levels was significantly higher in PV patients than in control subjects (11.99 +/- 1.63 pg/m vs. 1.83 +/- 0.22 pg/ml; P-value = 0.0001).
Elevated MIF levels in the sera of PV patients could participate in disease induction by activation of T cells as well as induction of autoantibody production by B cells. Given that MIF counter-regulates the effects of steroids, MIF antagonists may prove to be very effective, novel steroid-sparing agents for this life-threatening conundrum.
有充分的证据表明巨噬细胞移动抑制因子（MIF）参与自身免疫和炎症性疾病。
本研究旨在确定寻常型天疱疮（PV）患者血清中 MIF 水平是否升高。
采用 ELISA 法检测 22 例活动期 PV 患者和 21 例年龄和性别匹配的健康对照者血清 MIF 水平，并进行比较。
PV 患者血清 MIF 水平明显高于对照组（11.99±1.63pg/ml 比 1.83±0.22pg/ml；P 值=0.0001）。
PV 患者血清中升高的 MIF 水平可能通过激活 T 细胞以及诱导 B 细胞产生自身抗体参与疾病的诱导。鉴于 MIF 可抵消类固醇的作用，MIF 拮抗剂可能被证明是治疗这种危及生命的难题的非常有效、新颖的类固醇节约剂。
