Strote G, Brattig N W, Tischendorf F W
Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, F.R.G.
Acta Trop. 1990 Oct;48(1):1-8. doi: 10.1016/0001-706x(90)90059-9.
The interaction in vitro between eosinophil effector cells and third and fourth stage larvae of Onchocerca volvulus was studied by electron microscopy. The morphological observations demonstrated different mechanisms of attack of eosinophil cells that are dependent upon the time of incubation. Rapid adherence to the cuticle of the target, flattening, secretion of granule contents, vacuole formation and, finally, complete degranulation of the eosinophils were seen after incubation with third stage larvae and moulting stages. Alterations of the epicuticular and cuticular structures could be found near the attachment site of the cells. The eosinophils, however, showed no interactions with fourth stage larvae of this filarial parasite.
通过电子显微镜研究了嗜酸性效应细胞与盘尾丝虫第三和第四期幼虫之间的体外相互作用。形态学观察表明，嗜酸性细胞的攻击机制不同，这取决于孵育时间。与第三期幼虫和蜕皮阶段孵育后，可见嗜酸性粒细胞迅速黏附于靶标表皮、扁平化、颗粒内容物分泌、液泡形成，最终完全脱颗粒。在细胞附着部位附近可发现表皮和角质层结构的改变。然而，嗜酸性粒细胞与这种丝虫寄生虫的第四期幼虫没有相互作用。
