Costa Luciola da C Menezes, Maher Christopher G, McAuley James H, Hancock Mark J, Herbert Robert D, Refshauge Kathryn M, Henschke Nicholas
George Institute for International Health, University of Sydney.
BMJ. 2009 Oct 6;339:b3829. doi: 10.1136/bmj.b3829.
To describe the course of chronic low back pain in an inception cohort and to identify prognostic markers at the onset of chronicity.
Inception cohort study with one year follow-up.
Primary care clinics in Sydney, Australia.
The study sample was a subcohort of an inception cohort of 973 consecutive patients presenting to primary care with acute low back pain (<2 weeks' duration). 406 participants whose pain persisted for three months formed the inception cohort of patients with chronic low back pain.
Outcomes and putative predictors measured at initial presentation, onset of chronicity (study entry), and follow-up at nine and 12 months. Recovery was determined from measures of pain intensity, disability, and work status. The association between potential prognostic factors and time to recovery was modelled with Cox regression.
Completeness of follow-up was 97% of total person time for all outcomes. The cumulative probability of being pain-free was 35% at nine months and 42% at 12 months and for complete recovery was 35% at nine months and 41% at 12 months. Of the 259 participants who had not recovered from pain related disability at entry to the chronic study, 47% had recovered by 12 months. Previous sick leave due to low back pain, high disability levels or high pain intensity at onset of chronicity, low levels of education, greater perceived risk of persistent pain, and being born outside Australia were associated with delayed recovery.
More than one third of patients with recent onset, non-radicular chronic low back pain recover within 12 months. The prognosis is less favourable for those who have taken previous sick leave for low back pain, have high disability levels or high pain intensity at onset of chronic low back pain, have lower education, perceive themselves as having a high risk of persistent pain, and were born outside Australia.
描述一个起始队列中慢性下腰痛的病程,并确定慢性期开始时的预后标志物。
进行为期一年随访的起始队列研究。
澳大利亚悉尼的基层医疗诊所。
研究样本是一个起始队列的亚组,该起始队列由973名因急性下腰痛(病程<2周)前来基层医疗就诊的连续患者组成。406名疼痛持续三个月的参与者构成了慢性下腰痛患者的起始队列。
在初次就诊、慢性期开始(研究入组)以及9个月和12个月随访时测量的结局和假定预测因素。根据疼痛强度、残疾程度和工作状态的测量结果确定恢复情况。使用Cox回归对潜在预后因素与恢复时间之间的关联进行建模。
所有结局的随访完整性为总人时的97%。9个月时无痛的累积概率为35%,12个月时为42%;完全恢复的累积概率9个月时为35%,12个月时为41%。在进入慢性研究时未从与疼痛相关的残疾中恢复的259名参与者中,47%在12个月时已恢复。既往因下腰痛病假、慢性期开始时残疾水平高或疼痛强度高、教育水平低、认为持续疼痛风险高以及出生在澳大利亚境外与恢复延迟相关。
超过三分之一近期发病、非根性慢性下腰痛患者在12个月内恢复。对于那些既往因下腰痛请过病假、慢性下腰痛开始时残疾水平高或疼痛强度高,、教育水平较低、认为自己持续疼痛风险高以及出生在澳大利亚境外的患者,预后较差。