Clarke A M, Zemcov S J
Lions Gate Hospital, North Vancouver, B.C., Canada.
J Antimicrob Chemother. 1981 Sep;8 Suppl B:57-62. doi: 10.1093/jac/8.suppl_b.57.
Ceftazidime and ceftriaxone (Ro 13-9904), two new parenteral cephalosporins, were compared with other beta-lactam antibiotics against a total of 237 recent clinical isolates. Both ceftazidime and ceftriaxone had good activity against the Enterobacteriaceae, with 90% of isolates being inhibited by 0.5 mg/l of ceftazidime and by 0.25 mg/l of ceftriaxone. Against Pseudomonas aeruginosa, ceftazidime was about four times more active than ceftriaxone which, in turn, was at least eight times more active than carbenicillin. Both ceftazidime and ceftriaxone were highly active against beta-lactamase producing and non-beta-lactamase producing Haemophilus influenzae. Against the Bacteroides fragilis group, neither ceftazidime nor ceftriaxone showed good activity, the MIC90 for ceftazidime being > 128 mg/l and the MIC90 for ceftriaxone being 32 mg/l. Both ceftazidime and ceftriaxone were less active than cephalothin against Staphylococcus aureus.
头孢他啶和头孢曲松（Ro 13-9904）这两种新型肠胃外头孢菌素，与其他β-内酰胺类抗生素针对总共237株近期临床分离菌进行了比较。头孢他啶和头孢曲松对肠杆菌科细菌均具有良好活性，90%的分离菌可被0.5mg/L的头孢他啶和0.25mg/L的头孢曲松抑制。针对铜绿假单胞菌，头孢他啶的活性约为头孢曲松的四倍，而头孢曲松的活性又至少是羧苄西林的八倍。头孢他啶和头孢曲松对产β-内酰胺酶和不产β-内酰胺酶的流感嗜血杆菌均具有高活性。针对脆弱拟杆菌属，头孢他啶和头孢曲松均未表现出良好活性，头孢他啶的MIC90＞128mg/L，头孢曲松的MIC90为32mg/L。头孢他啶和头孢曲松对金黄色葡萄球菌的活性均低于头孢噻吩。
