Hansen Torsten, Kunkel Martin, Katenkamp Detlef, Eletr Sami, Wagner Wilfried
Institute of Pathology, Johannes Gutenberg University of Mainz, Langenbeckstr. 1, 55101 Mainz, Germany.
Oral Maxillofac Surg. 2009 Dec;13(4):239-42. doi: 10.1007/s10006-009-0172-6.
Intraosseous hemangioma of the mandible is a rare tumor. In this report, we present a case with a particularly prominent osteolysis and discuss the histological features of bone degradation.
We describe a 64-year-old female patient with a cystic tumor mass of the mandible leading to pathologic bone fracture. X-ray analysis was suggestive for aneurysmatic bone cyst. A segment resection was performed.
The histological examination revealed a mesenchymal tumor with numerous capillaries and dilated vessels immunohistochemically being positive for CD31, but not for D2-40. In addition, there was a remarkable increase of osteoclasts that sometimes exhibited Howship's lacunae. The tumor was diagnosed as intraosseous hemangioma with prominent bone degradation.
Based on our histological findings, it should be further investigated whether there could be an association between angiogenesis and osteoclastogenesis as a central pathway leading to bone destruction in the case of intraosseous hemangiomas.
下颌骨骨内血管瘤是一种罕见的肿瘤。在本报告中，我们呈现了一例具有特别显著骨质溶解的病例，并讨论骨降解的组织学特征。
我们描述了一名64岁女性患者，其下颌骨有一个囊性肿瘤肿块，导致病理性骨折。X线分析提示为动脉瘤样骨囊肿。进行了节段性切除。
组织学检查显示为间叶性肿瘤，有大量毛细血管和扩张血管，免疫组化显示CD31阳性，但D2-40阴性。此外，破骨细胞显著增多，有时可见哈弗斯陷窝。该肿瘤被诊断为伴有显著骨降解的骨内血管瘤。
基于我们的组织学发现，应进一步研究在骨内血管瘤病例中，血管生成与破骨细胞生成之间是否可能存在关联，这是导致骨破坏的核心途径。
