Fujita T, Nakatani E, Funaishi N, Sakuma S, Fujimoto Y
Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Japan.
J Pharm Pharmacol. 1990 Sep;42(9):655-7. doi: 10.1111/j.2042-7158.1990.tb06626.x.
The effect of selenium ions on prostaglandin (PG) catabolism and synthesis in rabbit gastric antral mucosal slices has been examined. Selenium ions had a potent inhibitory effect on the inactivation process for PGE2 and PGF2 alpha. Simultaneously, the levels of PGE2 and PGF2 alpha were increased. These results suggest that selenium ions have the potential to increase the levels of biologically active PGs in gastric mucosa by preventing their inactivation and that this effect may represent some pharmacological action of selenium ions.
研究了硒离子对兔胃窦黏膜切片中前列腺素（PG）分解代谢和合成的影响。硒离子对PGE2和PGF2α的失活过程具有强烈的抑制作用。同时，PGE2和PGF2α的水平升高。这些结果表明，硒离子有可能通过防止生物活性PG失活来提高胃黏膜中其水平，并且这种作用可能代表了硒离子的某些药理作用。
