Kasahara M, Matsumura E, Webb G, Board P G, Figueroa F, Klein J
Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101.
Genomics. 1990 Sep;8(1):90-6. doi: 10.1016/0888-7543(90)90229-n.
Recombinant inbred strains of mice were used to localize the genes coding for the class alpha glutathione S-transferase 2 (Gst-2). The genes showed three distinct strain distribution patterns, indicating that they occur in at least three clusters separable by recombination. All three clusters are located in the vicinity of the d locus on mouse chromosome 9, but two of them are closer to d than the third. Linked to Gst-2 on mouse chromosome 9 are two enzyme-encoding loci, Pgm-3 and Mod-1. The human counterparts of Gst-2, Pgm-3, and Mod-1 map to 6p12, 6q12, and 6q12, respectively. Thus, the pericentric region of human chromosome 6 has its homolog in the segment spanning Gst-2, Pgm-3, and Mod-1 on mouse chromosome 9. The fact that the syntenic group extends across the centromere of human chromosome 6 can best be explained by a pericentric inversion postulated to have taken place in the primate lineage leading to Catarhini.
利用重组近交系小鼠来定位编码α类谷胱甘肽S-转移酶2（Gst-2）的基因。这些基因呈现出三种不同的品系分布模式，表明它们至少存在于三个可通过重组分离的簇中。所有这三个簇都位于小鼠9号染色体上d位点附近，但其中两个比第三个更靠近d位点。与小鼠9号染色体上的Gst-2连锁的是两个编码酶的基因座，即Pgm-3和Mod-1。Gst-2、Pgm-3和Mod-1在人类中的对应基因分别定位于6p12、6q12和6q12。因此，人类6号染色体的着丝粒周围区域在小鼠9号染色体上跨越Gst-2、Pgm-3和Mod-1的片段中有其同源区域。同线群延伸至人类6号染色体着丝粒这一事实，最合理的解释是假定在导致狭鼻猴类的灵长类谱系中发生了一次着丝粒周围倒位。
