来自中国鼠疫自然疫源地的鼠疫耶尔森氏菌分离株的基因组序列草图
Draft genome sequences of Yersinia pestis isolates from natural foci of endemic plague in China.
作者信息
Eppinger Mark, Guo Zhaobiao, Sebastian Yinong, Song Yajun, Lindler Luther E, Yang Ruifu, Ravel Jacques
机构信息
Department of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland, School of Medicine, Baltimore, MD, USA.
出版信息
J Bacteriol. 2009 Dec;191(24):7628-9. doi: 10.1128/JB.01227-09. Epub 2009 Oct 9.
Abstract
To gain insights into the evolutionary origin, emergence, and pathogenicity of the etiologic agent of plague, we have sequenced the genomes of four Yersinia pestis strains isolated from the zoonotic rodent reservoir in foci of endemic plague in China. These resources enable in-depth studies of Y. pestis sequence variations and detailed whole-genome comparisons of very closely related genomes from the supposed site of the origin and the emergence of global pandemics of plague.
摘要
为深入了解鼠疫病原体的进化起源、出现及致病性，我们对从中国鼠疫流行疫源地的啮齿动物宿主中分离出的4株鼠疫耶尔森菌进行了全基因组测序。这些资源有助于深入研究鼠疫耶尔森菌的序列变异，并对来自假定起源地及全球鼠疫大流行发源地的高度相近基因组进行详细的全基因组比较。
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