Public Health Sciences Section, Division of Community Health Sciences, Centre for Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, EH8 9AG Edinburgh, Scotland, UK.
Behav Genet. 2010 Jan;40(1):3-11. doi: 10.1007/s10519-009-9302-z. Epub 2009 Oct 10.
It is unknown whether the relationship between raised inflammatory biomarker levels and late-life cognitive ability is causal. We explored this issue by testing the association between genetic regulators of plasma C-reactive protein (CRP) and cognition. Data were analysed from four cohorts based in central Scotland (Total N = 4,782). Associations were tested between variants in the CRP gene and both plasma CRP levels and a battery of neuropsychological tests, including a vocabulary-based estimate of peak prior cognitive ability and a general (summary) cognitive factor score, or 'g'. CRP levels were associated with a number of variants in the CRP gene (SNPs), including rs1205, rs1130864, rs1800947, and rs1417938 (P range 4.2e-06 to 0.041). Higher CRP levels were also associated with vocabulary-adjusted cognitive ability, used here to estimate lifetime cognitive change (P range 1.7e-04 to 0.038). After correction for multiple testing and adjustment for age and sex, no statistically significant associations were found between the SNPs and cognition. CRP is unlikely to be a causal determinant of late-life cognitive ability.
目前尚不清楚炎症生物标志物水平升高与晚年认知能力之间的关系是否具有因果关系。我们通过测试血浆 C 反应蛋白（CRP）的遗传调节因子与认知之间的关联来探讨这个问题。数据分析来自于苏格兰中部的四个队列（总计 N=4782）。在 CRP 基因中的变异与血浆 CRP 水平以及一系列神经心理学测试之间进行了关联测试，包括基于词汇的先前认知能力峰值估计和一般（综合）认知因子评分，或“g”。CRP 水平与 CRP 基因中的许多变异有关（SNP），包括 rs1205、rs1130864、rs1800947 和 rs1417938（P 范围为 4.2e-06 至 0.041）。较高的 CRP 水平也与词汇调整后的认知能力相关，这里用于估计终生认知变化（P 范围为 1.7e-04 至 0.038）。在进行多次测试校正和年龄与性别调整后，SNP 与认知之间没有发现统计学上显著的关联。CRP 不太可能是晚年认知能力的因果决定因素。
