Brandt K D, Albrecht M
Indiana University School of Medicine, Indianapolis 46202-5103.
J Pharm Pharmacol. 1990 Oct;42(10):738-40. doi: 10.1111/j.2042-7158.1990.tb06573.x.
The effects of the non-steroidal anti-inflammatory drug, naproxen sodium, on the metabolism of normal canine articular cartilage has been examined. At a concentration approaching that achieved in synovial fluid of patients treated with the drug (i.e. 30 micrograms mL-1) naproxen sodium had no significant effect on net synthesis of either glycosaminoglycans or protein in organ cultures of femoral condylar cartilage, nor did it increase the proportion of newly synthesized glycosaminoglycans recovered from the culture medium, suggesting that it had no direct effect on the integrity of the extracellular matrix.
已对非甾体抗炎药萘普生钠对正常犬关节软骨代谢的影响进行了研究。在接近接受该药物治疗患者滑液中所达到的浓度（即30微克/毫升）时，萘普生钠对股骨髁软骨器官培养物中糖胺聚糖或蛋白质的净合成没有显著影响，也未增加从培养基中回收的新合成糖胺聚糖的比例，这表明它对细胞外基质的完整性没有直接影响。
