Loftin Erika G, Herold Lee V
DoveLewis Emergency Animal Hospital, Portland, OR97209, USA.
J Vet Emerg Crit Care (San Antonio). 2009 Oct;19(5):501-6. doi: 10.1111/j.1476-4431.2009.00460.x.
To report a suspected toxicity in 2 dogs; to discuss therapy and prognosis.
Suspected alpha lipoic acid (ALA) toxicity was diagnosed based on clinical history and compatible laboratory findings in 2 dogs. Case 1 was presented within 10 hours of ALA ingestion, with initial behavioral changes likely due to hypoglycemia. During the course of hospitalization, hypoglycemia persisted and evidence of acute hepatic insult developed. With aggressive supportive care (including IV fluids with dextrose supplementation, hepatoprotective medications, and a plasma transfusion), he made a full recovery. Case 2 was presented approximately 60 hours after ALA ingestion, and was found to be in oliguric renal failure. She was treated with IV fluids, gastroprotective medications, and furosemide, but her condition deteriorated and she was ultimately euthanized within 16 hours of admission to the hospital.
ALA is an uncommon but serious toxin that should be considered in cases presenting with hypoglycemia, acute renal failure, or acute hepatic insult.
报告2只犬疑似中毒病例；讨论治疗方法及预后。
根据临床病史及相符的实验室检查结果，诊断2只犬疑似α硫辛酸（ALA）中毒。病例1在摄入ALA后10小时内就诊，最初的行为改变可能是由低血糖引起的。在住院期间，低血糖持续存在，并出现急性肝损伤的迹象。经过积极的支持治疗（包括补充葡萄糖的静脉输液、保肝药物和输血），它完全康复。病例2在摄入ALA后约60小时就诊，被发现处于少尿性肾衰竭状态。她接受了静脉输液、胃保护药物和呋塞米治疗，但病情恶化，最终在入院16小时内实施了安乐死。
ALA是一种不常见但严重的毒素，在出现低血糖、急性肾衰竭或急性肝损伤的病例中应予以考虑。
